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Metabolic Nutrition Synedrex 45 Caps

Metabolic Nutrition Synedrex 45 Caps

Sku: 764779324599
  • Buy 2 for $39.99 each and save 12%

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Metabolic Nutrition Synedrex 45 Caps

WARNING: This is the new formula. Feedback tells us this is much stronger than the previous versions. Only use if you are tolerant of strong stimulants.

What is Synedrex?

Metabolic Nutrition Synedrex is a high quality performance fat burner that contains potent thermogenic ingredients to get you shredded. Synedrex contains the world's first 4 step metabolic accelerator. SYNEDREX works by addressing the 4 problem areas which can slow your metabolic rate. SyneDrex is a research-designed gel-cap that stimulates metabolic receptors to burn calories faster. SyneDrex begins to work instantly to increase your metabolic rate. Since metabolism varies from person to person, fat loss results will vary.


  • Speeds Up Your Metabolism
  • Burn More Body Fat
  • Control Appetite
  • Quick, Extended Energy – No Crash!


  • Increases your caloric burn each and every day
  • Stimulates your Energy Levels
  • Controls carbohydrates for maintaining a healthy blood sugar level to control sugar cravings
  • Controls your Hunger so that you spend more time living life than looking for something to eat


Metabolic Nutrition recommends that you only take 1 capsule per 24 hours. Due to the strength and potency of Synedrex it is highly recommended that for the first few days take with food. Then once tolerance is accessed, take in the morning on an empty stomch. Do not exceed more than 1 capsule per day or 12 hours before bedtime!


Servings Per Bottle: 45
Serving Size: 1 Capsule

Synedrex Formulated Weight Loss Solution Blend: 614mg

Caffeine Anhydrous*
Eria Jarensis Extract*
Grains of Paradise (as Paradoxine)*
Bitter Orange Extract*
Yohimbine HCL: *
Huperzine A

Other Ingredients: Talc, Calsium Carbonate, Silicone Dioxide, Magnesium Stearate, FD & C Blue 1, Red 40, Gelatin

Note: This formula no longer has 1,3 DMAA in it

Label / Supplement Facts


Synedrex Label

Additional Information

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  • From Carrie at 9/10/2015 5:15 PM
    • What happens if I use it for longer then 60 days?
    • Some people do use Synedrex for longer, but it's best to give your body a break from stimulants after that long of use. You could switch to a non-stimulant fat loss product liek Thyrene or Hydravax...and then go back to this again 4 weeks or so later.
  • From dave at 9/20/2015 7:09 PM
    • could there be any bad side effects ....if I take Synedrex in the morning and Tylenol or Ibuprofen at evening/night ??
    • There shouldn't be any negative side effects, as doing that is common among bodybuilders and athletes. But if you do have concerns, we would recommend speaking with your doctor.
  • From Ben at 9/25/2015 9:01 AM
    • If I take one in the morning before work, am I able to still take a pre workout before the gym that day? Does mixing this with pre/post workout powders have any side effects/problems?
    • Yes you definitely can. Just make sure to get at least 4-6 hours between taking one capsule of Synedrex and your pre-workout supplement. You can also mix this with a pre-workout as long as it is non-stimulant. We would not recommend taking a stimulant fat burner and a stimulant pre-workout at the same time together.
  • From Caroline at 1/14/2016 4:53 PM
    • Can this make me "pop hot" on a drug test? Or is there any ingredient not listed? I know the old formula had that 1 3 dimethylamylamine in it and I was not allowed to take it.
    • No, there shouldn't be anything in here that would make you fail a drug test. Now it really depends on what they are testing for though. This formula does have Amp Citrate, but not 1,3 DMAA.
  • From Chase at 1/28/2016 5:35 PM
    • Is it okay if I take this while taking l-carnitine and pre workout? I do not use pre workout daily but I use it frequently.
    • You can stack it with the L-Carnitine no problem. As far as the pre-workout, you have a couple options. Stack it with a non-stimulant pre-workout or don't take it within 4-6 hours of your pre-workout supplement.
  • From Andy at 3/6/2016 2:01 PM
    • What happens if you drink alcohol, caffeine or sugar while taking this?
    • It is not recommended to take in alcohol or caffeine from other sources at the same time as taking this. Now if you take this in the morning, and drink at night or take in other caffeine at night, that is no problem.
  • From Andy at 3/9/2016 10:47 AM
    • Good morning. I have a question with regards to the amount of pills taken in a day. I noticed it says to take one pill for three days, and after that you can take two. What I'm a bit confused on is if after the third day you take two at a time, or you take one in the morning, or if you take one in the morning and then another one four or five hours later?
    • In the beginning you are just accessing your tolerance. Once your tolerance is accessed, you can do it two ways. Taking both at the same time, or if that is too strong, take one upon waking and another 4-6 hours later. Just don't take in the afternoon or evening, as it can keep you up at night due to the strength.
  • From Paola at 4/11/2016 4:35 PM
    • What is the expiration date of the product? I'm thinking about buying like 4 at the same time...
    • Our current stock (as of 04/12/2016) of Synedrex expires 07/2018, so you have over two years left on each bottle.
  • From dave at 5/8/2016 7:13 PM
    • I'm taking Pantoprazole for g.e.r.d. would it be safe to take synedrex ? still....I went through a whole bottle of one already of synedrex...but I still have one unopened bottle it expires 2018..since they barely discover I have gastro esophageal reflux diseas..
    • You would need to speak to your doctor. Anyone having any sort of medical condition or taking a prescription medication should always speak to their doctor before taking any type of dietary supplement.
  • From M at 6/7/2016 4:24 PM
    • Is this the original formula with DMAA or the newly formulated product?
    • Synedrex hasn't had 1,3 DMAA in it for about 2-3 years. It was reformulated about 2 years ago with AMP Citrate. Now the newest version doesn't have AMP Citrate, but all our bottles still have the formula with AMP Citrate, which is the one you want. If you are looking for a product with 1,3 DMAA we would recommend HydroxyElite Pro or Lipodrene, both which you can find at MySupplementStore.com. Hope this helps!
  • From Salina at 7/24/2016 10:28 PM
    • Does the bottle have meridextrine in it?
      Ti02 in it?
    • This is what Metabolic Nutrition told us:

      "Meridextrin is a fine-particle core product that is a mechanically stable granulate consisting of spherical particles with an average size of about 30 micrometers (or 30 millionths of a meter). The highly porous granules of pure silicon dioxide are eminently suitable as carrier substances for active ingredients that must be incorporated into powder formulations in precise measurements. Meridextrin also prevents interaction between ingredients to preserve the chemical structure of each active so that it maintains it intended functionality…and by this same nature it can exhibit a time-release functionality as well."
  • From Gold at 7/19/2017 7:13 AM
    • Is this the same Synedrex that was being sold in 1999-2000???
    • We don't believe Synedrex was around back in 1999-2000. This is now the 4th version of the product. According to Metabolic Nutrition, this new version is the strongest they have ever released.
  • From Patrick at 8/12/2017 3:20 AM
    • Is this a different version of syndrene?
    • There have been a few versions of Synadrene over the past few years. The first version had 1,3 DMAA as the main ingredient, the second version just had loads of caffeine, the 3rd version has amp citrate and now this 4th version is a huge change, but customers seem to like it. Really heats them up and the energy boost lasts for hours and hours. That's why it is an only one pill per day supplement.

Customer Reviews

5 Stars (37)
4 Stars (5)
3 Stars (3)
2 Stars (3)
1 Stars (3)
Feb 19, 2018
This is a strong fat burner. It works extremely well but may not be tolerated by everyone. You can feel it working.
*DISCLAIMER. Individual results may vary.
Feb 16, 2018
Ricardo Hernandez
I always go back to this fat burner. None make me feel the energy and the burn like this one does. But I take it every other day until I feel and look good where I’m at and then I drop the dosage down to once or twice a week
*DISCLAIMER. Individual results may vary.
Jan 07, 2018
I have never had a nice sick pack, but after using this and exercising the same, I saw results I never thought was possible.
*DISCLAIMER. Individual results may vary.
Oct 17, 2017
I bought two bottles of this one not realizing it was a different formula. I have been taking these supplements for ages including Ephedra back in the day and I never had a reaction like this. Nose running, gagging, throwing up, blood shot eyes and the shakes. However, it does what it's supposed to. I am wondering if it's something to get used to.
*DISCLAIMER. Individual results may vary.
Oct 03, 2017
I previously used synadrene, which worked wonderfully for me. I tried synadrex assuming it would be close to the same for me- boy was I wrong.
While I was able to lose weight with this product the side effects were awful. I was nauseous all the time, unable to sleep, my bowel movements were multiple times daily, and extremely loose, and I was so jittery.
The worst part is that it messed up my monthly cycle. My menstruation became "The Never Ending Story", and lasted for 14 days. There was a 2 days pause, and it resumed again.
This product was complete and utter chaos to my sex life, as it robbed me of my natural lubricants, and who wants to be intimate when you are bleeding.
Never again would I use this product. The side effects lasted for several days after I stopped taking the product, and the consequences were not worth the price of admission in my opinion.
*DISCLAIMER. Individual results may vary.
Sep 18, 2017
I have been consistently taking Synedrex for almost a month. Prior I have taken Synedrene, Lipodrene, and others without any problems. Synedrex gives me chills, makes me very jittery and even gives me nausea in the morning. It is great for appetite control but this stuff is "no joke" and definitely not for beginners. Strokes run in my family and this is not worth the risk.
*DISCLAIMER. Individual results may vary.
Sep 18, 2017
I love this supplement. I do take it with a bit of food early in the morning. I am not too sensitive to caffeine so I do not get the jitters like others have posted. Sometimes I get a little hot but it is not anything that would prevent me from using it. When I use this supplement I have no need for extra coffee or energy drinks. Highly recommend!
*DISCLAIMER. Individual results may vary.
Sep 17, 2017
I previously used synadrene, which worked well enough for me.
With synadrex I feel coked out. My heart races, I feel jittery, and I have the shakes. The weight loss isn't worth feeling like I am on the cusp of a stroke every time I take it. I would not buy again.
*DISCLAIMER. Individual results may vary.
Aug 25, 2017
41 year old female, approximately 130 lbs and work-out 4-6 times/week.

I was super excited to learn they had a new formula of Syndrex available in August. I tried the old formula a couple of years ago and was pretty impressed with the energy boost, decreased appetite etc. The new formula, in my opinion, is dangerous. Within 30 minutes (I timed it) this little red and white pill kicks in. Literally kicking my butt. It increases my heart rate like I was running a marathon at full speed. So any form of cardio has to be scaled back to avoid a heart attack on the road/treadmill. To date, I have not taken a full dose of this new formula due to its potency. I have experienced nausea and vomiting while using this product after and during a run. Please use caution when using this new formula, if you have been using this for some time and no effects.... Great for you, but those who are just trying it out for the first time, please cut your pill in half until you know how it will effect you. IT CERTAINLY BURNS FAT, gives you energy, but makes you feel exhausted due to the increased heart rate. I have used this formula before. I have used OxyElite Pro when it was on the market. I have used Synadrene(full pill), which was a replacement for Syndrex when they originally took it off the market. I just want people to know that a full dose of this new Syndrex could cause some major heart problems if you are not careful. It might be better to just dissolve this little pill in water and sip on that for a bit.
*DISCLAIMER. Individual results may vary.
Aug 07, 2017
Katie Lawrence
This stuff is amazing pre-run. I never have gotten so sweaty as when taking this. I have dropped a few pounds in just a couple days. Mostly water probably but still. This works great. Loved the old formula so glad its back!
*DISCLAIMER. Individual results may vary.
Aug 04, 2017
I'm sure this works for some people, but I took this for the first time with food as directed. Not even an hour later I was running to the bathroom throwing up and continued to throw up for the next two hours. Had to go to the doctor to get Zofran so I could keep my water down. Gave me the worst shakes and made my blood pressure so high my eyes started to bulge. My blood pressure is usually in the normal range. Awful experience. I guess this is for people who take high stimulant supplements regularly.
*DISCLAIMER. Individual results may vary.
May 10, 2017
Do not recommend taking this if you are on other mood modifying medications. Felt no extra energy, no elevated heart rate, did not suppress my appetite and actually did the opposite of what I was hoping. Lost all motivation and had depressive feelings with mood swings. Highly caution anyone with a mood disorder or on prescribed mood modification medications.
*DISCLAIMER. Individual results may vary.
Oct 21, 2016
Yes it worked Great. I've taken it before and love the way it makes me feel.
*DISCLAIMER. Individual results may vary.
Sep 13, 2016
Finally a product that helped me lose extra weight. This along with a diet will really help!
*DISCLAIMER. Individual results may vary.
Sep 07, 2016
Awesome fat burner. Feel great on it. I just stocked up as I heard this is going to be discontinued.
*DISCLAIMER. Individual results may vary.
Sep 02, 2016
Love this fat burner. Always works for me.
*DISCLAIMER. Individual results may vary.
Jul 20, 2016
By far the best fat burner out there..!!!!!
*DISCLAIMER. Individual results may vary.
Jun 28, 2016
awesome. works amazing. was given some from a friend before. have lost 40lb!!! i have no appetite during the day. probably cause they make me feel like im in a constant state of mild nausea. but ill take it! seriously. never have i ever bought a diet pill that actually seemed to "work". theres a ton of other stuff in it though, and it definitely gives me a little bit of the shakes in the morning on an empty stomach but if i eat something small it goes away pretty quick. im on my second bottle now. ive only ever taken one a day. 2 would be crazy.
*DISCLAIMER. Individual results may vary.
Jun 22, 2016
By far the best supplement in this category!
*DISCLAIMER. Individual results may vary.
Jun 02, 2016
In my opinion, this is awesome. Helps boost energy. Keeps your mind off food throughout the day.
*DISCLAIMER. Individual results may vary.
May 11, 2016
Make sure you eat something before taking the pill. It does help curb your appetite. Hopefully it helps me lose some unwanted pounds.
*DISCLAIMER. Individual results may vary.
Mar 29, 2016
Seems would be good for ADHD/ADD people. This drug decreases my energy, appetite, and i didnt see any difference in my muscle tone vs testosterone supplements. I was excited to use this product, synerdrex, that was recommended to me. But so far have been disappointed. I have been using it daily for almost a week with no effects (besides some occasional gas and stomach cramps and loss of appetite ). I believe since I have a history of ADHD/ ADD That this product has AN OPPOSITE EFFECT. Usually stimulants with this population help slow down the individual and help them concentrate..and that's what I feel is happening to me...smh I do not get thirsty, excessive energy, or any other benefits out of this. I really was hoping for more energy while I worked out... I'm going to complete my bottle and then reflect . Hope this helps.
*DISCLAIMER. Individual results may vary.
Mar 25, 2016
Great.would buy again...
*DISCLAIMER. Individual results may vary.
Feb 27, 2016
yes it worked good!
*DISCLAIMER. Individual results may vary.
Feb 18, 2016
I use one before training with a protein shake or oatmeal. keeps me going and makes me sweat. I recommend drinking plenty of water as it makes you thirsty. I drink 4 -5 16.9oz bottles during workout.
*DISCLAIMER. Individual results may vary.
Feb 04, 2016
Definitely works as described - fantastic appetite suppressor
*DISCLAIMER. Individual results may vary.
Jan 20, 2016
Way better than I ever expected!
*DISCLAIMER. Individual results may vary.
Jan 13, 2016
I'm sure this is effective for others but it's definitely not for me. Today was the first day I took Metabolic Nutrition Synedrex. It was referred to me by the people at Nutrition Depot. They did warn me that if you do not do well on stimulants, to stay away from this product and go with an alternative. Since I've taken OxyElite Pro before and with pretty good results, I thought I'd be able to handle this. Well I've since realized, I can't. I'm sure this is effective for others and I'm almost positive that it works by reducing your appetite and help with weight loss but in this case, the side effects outweigh the pros. I took my first pill upon waking like the bottle suggests. It was 7:15am. By 7:30 I started to feel a bit "weird". I have an hour commute to work each morning and by 8:00am I felt it in full force. I had nausea, dry-heaving, the inability to control my body temperature, cold sweats, perspiration and tingly hands and feet! It kinda makes me feel like I'm on X to be honest with you. It's a horrible feeling; no wonder people don't eat with this. You feel too sick and too nauseated to put anything near your move. When I got to work around 8:30 am and thinking it would help - I ate a whole wheat bagel and cream cheese and drank a TON of water. By 11:30 am I was still feeling it's affects. I read that it can take anywhere between 15 hours and several days for it to pass through your system. The rep at Nutrition Depot said to give it at least 3 days but I don't think I can handle this again. I refuse to put myself through this so during lunch, I am returning this bottle. I have been on a diet an exercise program the last several months and cannot kick the last 15-20 pounds from after having a baby. I was hoping that this would help me supplement my regime and kick my ass into high gear and help me lose these last few pounds. This product however; is not for me and I DO NOT RECOMMEND this to anyone that is either sensitive to stims or have never taken a fat burner. Although I was able to handle OxyElite well, this one didn't go over too well with me. I will just have to continue looking for something that works for me instead of trying to conform to something that doesn't. I hope this review helps others decide if this is something that they should try -- or in my case, NOT.
*DISCLAIMER. Individual results may vary.
Oct 13, 2015
I've lost 55 lbs in just over 18 months. Great product!!!!
*DISCLAIMER. Individual results may vary.
May 23, 2015
I started taking synedrex when I got home from vacation last week (didn't know what type of side affects it would have on me and didn't want to risk it ruining my vacation) the first day I started I got incredibly hot and enough energy to last a week, had a little trouble sleeping but by day 2 that pretty much went away. I do need to eat before i take these in the morning, they suppress your appetite so much that you forget that you have not eaten all day until you lay down at night. They do give you a bit of cotton mouth which on my eyes is a good thing because it is making you drink alot of water! Today is day 7 of Taking these pills and I am down 10lbs! As I do not know the long term effect of these pills I can not give a full review but I will be back to let you know! Thanks so much for the awesome product!
*DISCLAIMER. Individual results may vary.
May 12, 2015
W0W ! This synedrex stuff is powerful . I take one pill 1st am while I get dressed for work and immediately it kicks in with the energy . I feel the energy thru the whole day ( I use to fall asleep @ work) I do not feel hungry but force myself to eat so I won't get sick . I made a big mistake one day and took one pill 1st am then took a second pill around 12:30 without eating and it freaked me out bad . it was way to much for me I could not even drive . please be careful and make sure you eat and drink water. the only strange side effect I get is chills . other than that this pill does wonders
*DISCLAIMER. Individual results may vary.
Apr 30, 2015
Very glad this Synedrex product is back after being off the market for part of last year (2014). If you are looking for appetite control/suppressant, look no further. You should take this with some food and be prepared to not get hungry for a long while and also to drink a lot of water as this makes me very thirsty. I've been about to lose over 50 lbs as i do not eat as much and give much needed energy to exercise after a long tiring day.
*DISCLAIMER. Individual results may vary.
Apr 12, 2015
I needed more enquiry and an appetite suppressant. This product is amazing with both of these issues! I will order this product again!
*DISCLAIMER. Individual results may vary.
Mar 15, 2015
This was my very first time using Synedrex. I followed the directions as stated, but I took the one pill during lunch...a big NO NO. I did not go to sleep and crashed around 4AM. The pill definitelyu gave me the energy I was looking for, but I am not sure how long it will take for my body to adjust to it. The energy was unreal!
*DISCLAIMER. Individual results may vary.
Feb 19, 2015
Synedrex is definitely my magic pill! It gives me the energy, endurance and focus that I need. It leans me out by burning all body fat. This pill in combination with a healthy meal plan and good workout routine will work for just about anybody!
*DISCLAIMER. Individual results may vary.
Dec 14, 2014
I have used several of the fat burners available here and Syendrex is by far the best and most potent.
*DISCLAIMER. Individual results may vary.
Nov 20, 2014
My husband and I take synedrex regularly with breaks in between. Out of all of the weight loss supplements we have tried synedrex works the best. Synedrex gives you the focus and energy you need to get through the day and get through your workouts without the crash. Synedrex curbs your appetite and even when we take a break we don't notice intense weight gain like when you take other supplements. Synedrex works great with our body building routine. Highly recommended!

You must always follow a sensible diet!
*DISCLAIMER. Individual results may vary.
Sep 22, 2014
Just 1 pill a day and you will get the result you want. But drink a lot of fluids.
*DISCLAIMER. Individual results may vary.
Jul 09, 2014
Synedrex delivers results!!! No gimmicks if you tried all other diet supplements and felt disappointed you will not regret using Synedrex!! 1 pill a day its all it takes. Happy with results!!
*DISCLAIMER. Individual results may vary.
Jul 09, 2014
Awesome. Love it. So glad it's back!
*DISCLAIMER. Individual results may vary.
Jun 18, 2014
Lisa S.
I would def recommend Synedrex but only to those with good health. I would also only recommend one per day and not drink coffee or anything with caffeine in it as it will only enhance side effects. I love not feeling like I need to stuff my face with something. In fact food is the least on my mind. DO DRINK LOTS OF WATER, maybe a glass per hour. Also, if you feel no hunger even the next morning then skip a day taking the pill. It's only day three and i've lost 3lbs already. The first day is the hardest because your body is not use to it. I don't like coffee so I don't drink caffeine at all so when I first took this pill the side effects were a little strong. Then after the first day I felt better just slight pressure on my chest. Good luck and be safe and smart!
*DISCLAIMER. Individual results may vary.
May 13, 2014
This product is great but you need to be careful. When you first start taking it your body heats up, heart starts to race and your skin looks sunburnt from the active ingredients. Once you take it for a couple of days your body gets used to it and you can go on with your workout as intended to. The label says that once you get used to the effects you can take 2 pills upon waking up. I DO NOT RECOMMEND THIS! These pills are too powerful and you'll actuslly feel like shit for the majority of your day. I know this from experience as I had to cut my workout short the other day which NEVER happens. After going back to the one tablet in the morning I felt fine again the next few days and will never again take two pills in the morning. This is s great product that definitely helps you in the gym but you need to be cautious of how your body will react to the ingredients. If the one pill is too much for you in the beginning you can try opening the capsule and taking half of what is inside.

Hope telling you about my experiences with this product helps others who are looking to make a purchase
*DISCLAIMER. Individual results may vary.
Jan 22, 2014
this is the best!!
*DISCLAIMER. Individual results may vary.
Jan 13, 2014
I love this Synedrex stuff. It really has curbed my appetite. In 6 weeks ive lost over 16 lbs im more motivated and can work out longer.
*DISCLAIMER. Individual results may vary.
Jan 01, 2014
Bought these up before the sold out. Myself and many people I know have had great losses with this product.
*DISCLAIMER. Individual results may vary.
Dec 24, 2013
Synedrex is awesome! As long as I eat enough when I take it! If not I get pretty bad nausea. I also love the appetite suppressant. Down 4 pounds in 1 week so far.
*DISCLAIMER. Individual results may vary.
Dec 18, 2013
Big M
Took as a preworkout, gave more energy than any fat burner I have tried before. Even topped my favorite, SuperHD. I took it in the morning and didn't get any sleep the next night though. But Id definitely take it again
*DISCLAIMER. Individual results may vary.
Dec 09, 2013
Works effectively send me coupons so I can order more thanks guys have a Merry Christmas and a Happy New Year!!!!!!!
*DISCLAIMER. Individual results may vary.
Oct 26, 2013
I loved this product!!! It was a little pricey but worth every penny.
*DISCLAIMER. Individual results may vary.
Oct 21, 2013
This supplement is great as a meal suppressant...I didn't think about food at all which was great since I was dieting for a show and starving all the time. It also gave me really good positive energy with no crash.

I've had friends that have taken this product but they got different results...most of them experienced a severe increase in heart rate, but I'm not that sensitive to caffeine.

Definitely start out with one pill to assess your tolerance level.
*DISCLAIMER. Individual results may vary.
Aug 27, 2013
I'm excited about this product which was recomended by a body building friend. It gives me the energy I need to get through my daily work outs. I have noticed a significant loss of body fat and huge energy boost! I definitely recommend this product
*DISCLAIMER. Individual results may vary.

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