Research and empirical evidence have shown time and time again that immediately after weight training, taking advantage of specific physiological changes can exponentially accelerate changes in body composition and performance. With Protocol, not only will you allow your body to maximize the endogenous changes already caused by training, but you can actually support a perfect anabolic environment by driving your body's nutrient storage and muscle protein synthesis capabilities to a new level.
Genomyx Protocol was designed to be taken immediately after weight training to support protein synthesis and promote harmonization of your body's hormonal cascade priming it for a post workout meal or shake. Take a serving of Protocol right after training, wait 15 minutes and have a high carbohydrate, high protein shake or meal. For fat loss programs, take a serving of Protocol, wait 15 minutes and have an isocaloric (equal parts carb, protein and fat) mixed meal. The end result will be added support for muscle gain and recovery, fully preparing your body for the next training session. On non-training days, take a serving 15 minutes before your first meal.
Overview of ingredients and function
Leucine is a Branched Chain Amino Acid (BCAA's) concentrated highly in eggs, milk, beef, chicken and fish. Since Leucine is one of the few amino acids not metabolized by the liver, intake directly affects cellular concentrations. Numerous studies have suggested the ability of Leucine to prevent muscle protein breakdown and increase muscle protein synthesis (MPS) rates with promising results. Research suggests that Leucine acts as a primary signal alerting the body of amino acid availability for protein synthesis. This signaling causes an up-regulation of relevant anabolic machinery.
While insulin seems to enhance the effect of Leucine, multiple studies have proposed an additional non-insulin dependent effect of Leucine on MPS, which most discussions on the topic have overlooked. The relevant message is that Leucine will may support anti-catabolic and/or anabolic effect on its own through non insulin-dependent mechanisms, and will also have an additional effect when coupled with concurrent carbohydrate ingestion.
While all of the mechanisms Leucine uses to deliver its effects on muscle tissue have yet to be elucidated, research has suggested that it has an effect on mTOR activation, a key regulator of MPS. Aside from its mTOR effect, Leucine may also have anabolic effects unrelated to this pathway, as noted by Kimball and Jefferson in a 2001 study which suggested elevated muscle protein synthesis with no significant increase in mTOR signaling proteins.
Another way Leucine has been suggested to exhibit its beneficial effect on body composition is through its lesser known ability to promote muscle cell sensitivity. Research suggests that available Leucine may translate to increased uptake of all nutrients at the muscle cell, therefore support an increase in anabolism. Resistance training alone has been shown to upregulate MPS when adequate calories are supplied, yet the addition of Essential Amino Acids (EAA's, which include Leucine) may promote a much greater elevation. While initial studies on post workout MPS focused on BCAA's and EAA's, later studies have suggested that Leucine is the primary contributor to muscle tissue accretion, having the same or greater effect when taken alone vs. conjunction with the other BCAA's/EAA's.
Leucine may be useful when trying to retain lean body mass on a calorie restricted diet. Studies have suggested that supplemental Leucine may aid in the retention of LBM in a hypocaloric state and even suppress protein breakdown after 18 hours of starvation. While most weight training aficionados have known for some time that the RDA for protein is far from optimal when trying to change body composition, new research has suggested that during caloric restriction, daily requirements of certain amino acids, particularly Leucine, are drastically understated. In a 2008 review titled “Leucine for retention of lean mass on a hypocaloric diet”, researchers looked at a study that put various subjects on a 500 calorie/day deficit with various macronutrient intakes. The group on a high protein/high Leucine diet lost more weight, more fat, and showed greater LBM retention.
Whether using leucine to promote protein synthesis during a muscle gaining phase or minimize muscle loss and support fat loss while dieting, it should certainly hold a place in any physique enthusiast's repertoire and represents a crucial component in the Protocol formula.
• Activates mTOR
• Promote muscle protein synthesis
• Provide support against muscle protein breakdown
• Provide support against muscle loss on hypocaloric diet
• Promote muscle cell sensitivity
• Support anabolism through insulin-independent mechanisms
• The only amino acid to independently support the muscle building cascade
L-Carnitine L-Tartrate (LCLT) is a combination of the amino acid L-Carnitine and the salt of tartaric acid, with numerous potential benefits for those looking to improve body composition, performance and overall health.
One of LCLT's major benefits stems from its ability to directly support recovery from exercise, which may support muscle building and fat loss. Studies have suggested that supplementation with LCLT may help reduce the metabolic stress of exercise, enhance ammonia clearance at the muscle causing a favorable shift in pH, optimize recovery, and even reduce muscle soreness. Reduced soreness may not be a big seller for some people that don't mind a little post training discomfort, but looking at it in big picture terms, this may allow you to train again sooner and get more effective and frequent training sessions in throughout the week, month, or year leading to accelerated progress.
In a placebo controlled study published in 2008 by the big dogs William Kraemer and Jeff Volek (among others), the researchers suggested that ingestion of 2g/day of LCLT favorably shifted muscle cell oxygenation, (the balance between oxygen delivery and oxygen consumption) by enhancing oxygen consumption at the muscle cell. This may help support anaerobic as well as aerobic training.
LCLT has also gained recent attention when suggested that it may affect anabolic hormone signaling through multiple mechanisms. In a groundbreaking study published in Med Sci Sports Exerc., researchers found LCLT was able to increase muscle cell androgen receptor density which gives testosterone more sites to “dock”, and therefore could potentially support a large anabolic cascade.
L-Carnitine L-Tartrate Review
• Promotes androgen receptor density
• Support a reduction in markers of metabolic stress to exercise
• May promote a reduction in post workout soreness
• Supports optimal recovery from training
• Promote muscle cell oxygen consumption
Arginine is an amino acid that has made its way into countless bodybuilding supplements in the past few years, surrounded by endless promises about enhanced muscle pumps and heightened nutrient delivery. Most people have realized the incredulous amount of hyperbole involved in these claims and have begun to accept its muscle building potential to be far less than originally theorized. What does arginine have to do with agmatine? Once arginine is decarboxylated, it becomes agmatine. This decarboxylation entirely changes the nature of the compound in the body, so much so that agmatine is involved with even more metabolic processes than arginine itself.
Agmatine takes a two pronged attack to support nitric oxide production, by increasing NO synthesis as well as being an irreversible inhibitor of Nitric Oxide Synthase, which is the enzyme responsible for degradation of NO. By supporting NO production and decreasing its breakdown, the much sought after effects of vasodilatation and nutrient delivery to the muscle cells may be promoted. While it is debatable whether an increase in NO pre-workout is beneficial, most experts agree that a post workout elevation of NO may potentially support muscle recovery and enhance the anabolic signal cascade.
Agmatine is normally released endogenously in response to stress, by supplementing with an exogenous source, agmatine may support recovery. When using agmatine immediately after workouts, the nutrients digested in a post workout meal or shake may be more effectively delivered to the muscle cells for recovery and muscle growth.
Aside from the effects at the muscle cell, agmatine also possesses some interesting psychological effects. Studies have suggested that agmatine may support neuroprotective effects by blocking the damaging effects of excessive glutamate.
Agmatine Sulfate Review
• Supports Nitric Oxide synthesi
• Provide support against Nitric Oxide breakdown
• Promotes nutrient delivery to muscle cells
• Neuro-protective Support
• Promotes a Healthy, Positive Mood
For many years now research has continued to support the usage of this amino acid derivative for performance enhancement. Working in a similar, yet more efficient fashion as Citrulline Malate, Beta Alanine has been suggested to support muscle carnosine levels allowing for improvement in multiple areas of physical performance.
By buffering hydrogen (H+) ions, research suggests that may help increase aerobic and anaerobic performance especially muscular endurance in weight training and short and long duration sprinting. A recent study published in the peer reviewed journal Amino Acids suggested that supplementing with Beta Alanine was able to promote muscle carnosine levels.
Beta Alanine Review
• Support muscle carnosine levels
• Promote hydrogen ion buffering
• Promote muscular endurance
• Support for increased training volume
• Promote peak sprint power output
Ingredients (per serving) Dosage
Beta Alanine 2.0g
L-Carnitine L-Tartrate 1.0g
Agmatine Sulfate 500mg
Protocol may support the anabolic effect of weight training, support recovery, and promote body composition change. Optimize your post workout nutrition and support new growth.
Serving Size: 2 Scoop (12.8g)
Servings Per Container: 30
L-Leucine - 6.5g
Beta Alanine - 2g
L-Carnatine-L-Tartrate - 2g
Agmatine Sulfate - 500mg
Natural And Artificial Flavor, Citric Acid, Sucralose, Acesulfame
Genomyx Protocol Directions: Take one serving of Protocol right after workout, wait 15 minutes and have a high carbohydrate, high protein shake or meal.